The blurred border between porcine circovirus type 2-systemic disease and porcine respiratory disease complex.
Identifieur interne : 000240 ( Main/Exploration ); précédent : 000239; suivant : 000241The blurred border between porcine circovirus type 2-systemic disease and porcine respiratory disease complex.
Auteurs : G. Tic [Espagne] ; J. Segalés ; J. MartínezSource :
- Veterinary microbiology [ 1873-2542 ] ; 2013.
Descripteurs français
- KwdFr :
- ADN viral (analyse), Animaux (MeSH), Circovirus (génétique), Circovirus (physiologie), Espagne (épidémiologie), Hybridation in situ (MeSH), Immunohistochimie (MeSH), Infections à Circoviridae (anatomopathologie), Infections à Circoviridae (diagnostic), Infections à Circoviridae (médecine vétérinaire), Infections à Circoviridae (virologie), Infections à Circoviridae (épidémiologie), Maladies de l'appareil respiratoire (anatomopathologie), Maladies de l'appareil respiratoire (complications), Maladies de l'appareil respiratoire (diagnostic), Maladies de l'appareil respiratoire (médecine vétérinaire), Maladies de l'appareil respiratoire (virologie), Maladies de l'appareil respiratoire (épidémiologie), Maladies des porcs (anatomopathologie), Maladies des porcs (diagnostic), Maladies des porcs (virologie), Maladies des porcs (épidémiologie), Poumon (anatomopathologie), Poumon (virologie), Prévalence (MeSH), Suidae (MeSH), Tissu lymphoïde (anatomopathologie), Études rétrospectives (MeSH).
- MESH :
- analyse : ADN viral.
- anatomopathologie : Infections à Circoviridae, Maladies de l'appareil respiratoire, Maladies des porcs, Poumon, Tissu lymphoïde.
- diagnostic : Infections à Circoviridae, Maladies de l'appareil respiratoire, Maladies des porcs.
- génétique : Circovirus.
- médecine vétérinaire : Infections à Circoviridae, Maladies de l'appareil respiratoire.
- physiologie : Circovirus.
- virologie : Infections à Circoviridae, Maladies de l'appareil respiratoire, Maladies des porcs, Poumon.
- épidémiologie : Espagne, Infections à Circoviridae, Maladies de l'appareil respiratoire, Maladies des porcs.
- complications : Animaux, Hybridation in situ, Immunohistochimie, Maladies de l'appareil respiratoire, Prévalence, Suidae, Études rétrospectives.
English descriptors
- KwdEn :
- Animals (MeSH), Circoviridae Infections (diagnosis), Circoviridae Infections (epidemiology), Circoviridae Infections (pathology), Circoviridae Infections (veterinary), Circoviridae Infections (virology), Circovirus (genetics), Circovirus (physiology), DNA, Viral (analysis), Immunohistochemistry (MeSH), In Situ Hybridization (MeSH), Lung (pathology), Lung (virology), Lymphoid Tissue (pathology), Prevalence (MeSH), Respiratory Tract Diseases (complications), Respiratory Tract Diseases (diagnosis), Respiratory Tract Diseases (epidemiology), Respiratory Tract Diseases (pathology), Respiratory Tract Diseases (veterinary), Respiratory Tract Diseases (virology), Retrospective Studies (MeSH), Spain (epidemiology), Swine (MeSH), Swine Diseases (diagnosis), Swine Diseases (epidemiology), Swine Diseases (pathology), Swine Diseases (virology).
- MESH :
- chemical , analysis : DNA, Viral.
- complications : Respiratory Tract Diseases.
- diagnosis : Circoviridae Infections, Respiratory Tract Diseases, Swine Diseases.
- epidemiology : Circoviridae Infections, Respiratory Tract Diseases, Spain, Swine Diseases.
- genetics : Circovirus.
- pathology : Circoviridae Infections, Lung, Lymphoid Tissue, Respiratory Tract Diseases, Swine Diseases.
- physiology : Circovirus.
- veterinary : Circoviridae Infections, Respiratory Tract Diseases.
- virology : Circoviridae Infections, Lung, Respiratory Tract Diseases, Swine Diseases.
- Animals, Immunohistochemistry, In Situ Hybridization, Prevalence, Retrospective Studies, Swine.
Abstract
Porcine respiratory disease complex (PRDC) is the name used to describe a clinical presentation characterized by respiratory signs and poor growth in growing-finishing pigs. Porcine circovirus type 2 (PCV2) is one of the pathogens potentially involved in the presentation of this complex, although, it has been mainly linked to PCV2-systemic disease (PCV2-SD). However, some reports have suggested that PCV2 can cause respiratory lesions in the absence of systemic lymphoid damage; this apparently different condition has been referred as PCV2-lung disease (PCV2-LD). The present study analysed retrospectively the relation between PRDC and PCV2 infection from a pathological point of view. Of the 317 selected pigs suffering from PRDC and submitted for necropsy between 1998 and 2011, the most prevalent lesions were subacute interstitial pneumonia (27.7%) and the combination of subacute interstitial pneumonia plus catarrhal-purulent bronchopneumonia (28.4%). Two hundred and twenty-six pigs were positive for PCV2 by in situ hybridization (ISH); using immunohistochemical techniques, 77 were positive for porcine reproductive and respiratory syndrome virus and 3 for swine influenza virus. Among positive pigs for PCV2 ISH, 184 animals suffered from PCV2-SD. The rest of 42 PCV2 ISH positive pigs had no lymphoid lesions and low amount of viral nucleic acid in these tissues and, therefore, did not qualify for PCVD-SD; only 9 had concomitant PCV2 ISH positivity in the lung, also to a low amount. In conclusion, all PRDC-PCV2 ISH positive cases had evidence of viral systemic infection. These results suggest that PCV2-LD is probably a negligible condition and PCV2 mainly contributes to PRDC in relation to PCV2-SD occurrence.
DOI: 10.1016/j.vetmic.2013.01.001
PubMed: 23398668
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Tic</name><affiliation wicri:level="4"><nlm:affiliation>Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author><author><name sortKey="Segales, J" sort="Segales, J" uniqKey="Segales J" first="J" last="Segalés">J. Segalés</name></author><author><name sortKey="Martinez, J" sort="Martinez, J" uniqKey="Martinez J" first="J" last="Martínez">J. 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(virologie)</term><term>Infections à Circoviridae (épidémiologie)</term><term>Maladies de l'appareil respiratoire (anatomopathologie)</term><term>Maladies de l'appareil respiratoire (complications)</term><term>Maladies de l'appareil respiratoire (diagnostic)</term><term>Maladies de l'appareil respiratoire (médecine vétérinaire)</term><term>Maladies de l'appareil respiratoire (virologie)</term><term>Maladies de l'appareil respiratoire (épidémiologie)</term><term>Maladies des porcs (anatomopathologie)</term><term>Maladies des porcs (diagnostic)</term><term>Maladies des porcs (virologie)</term><term>Maladies des porcs (épidémiologie)</term><term>Poumon (anatomopathologie)</term><term>Poumon (virologie)</term><term>Prévalence (MeSH)</term><term>Suidae (MeSH)</term><term>Tissu lymphoïde (anatomopathologie)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>DNA, Viral</term></keywords><keywords 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respiratoire</term><term>Prévalence</term><term>Suidae</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Porcine respiratory disease complex (PRDC) is the name used to describe a clinical presentation characterized by respiratory signs and poor growth in growing-finishing pigs. Porcine circovirus type 2 (PCV2) is one of the pathogens potentially involved in the presentation of this complex, although, it has been mainly linked to PCV2-systemic disease (PCV2-SD). However, some reports have suggested that PCV2 can cause respiratory lesions in the absence of systemic lymphoid damage; this apparently different condition has been referred as PCV2-lung disease (PCV2-LD). The present study analysed retrospectively the relation between PRDC and PCV2 infection from a pathological point of view. Of the 317 selected pigs suffering from PRDC and submitted for necropsy between 1998 and 2011, the most prevalent lesions were subacute interstitial pneumonia (27.7%) and the combination of subacute interstitial pneumonia plus catarrhal-purulent bronchopneumonia (28.4%). Two hundred and twenty-six pigs were positive for PCV2 by in situ hybridization (ISH); using immunohistochemical techniques, 77 were positive for porcine reproductive and respiratory syndrome virus and 3 for swine influenza virus. Among positive pigs for PCV2 ISH, 184 animals suffered from PCV2-SD. The rest of 42 PCV2 ISH positive pigs had no lymphoid lesions and low amount of viral nucleic acid in these tissues and, therefore, did not qualify for PCVD-SD; only 9 had concomitant PCV2 ISH positivity in the lung, also to a low amount. In conclusion, all PRDC-PCV2 ISH positive cases had evidence of viral systemic infection. These results suggest that PCV2-LD is probably a negligible condition and PCV2 mainly contributes to PRDC in relation to PCV2-SD occurrence.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">23398668</PMID><DateCompleted><Year>2013</Year><Month>11</Month><Day>11</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-2542</ISSN><JournalIssue CitedMedium="Internet"><Volume>163</Volume><Issue>3-4</Issue><PubDate><Year>2013</Year><Month>May</Month><Day>03</Day></PubDate></JournalIssue><Title>Veterinary microbiology</Title><ISOAbbreviation>Vet. Microbiol.</ISOAbbreviation></Journal><ArticleTitle>The blurred border between porcine circovirus type 2-systemic disease and porcine respiratory disease complex.</ArticleTitle><Pagination><MedlinePgn>242-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.vetmic.2013.01.001</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0378-1135(13)00047-3</ELocationID><Abstract><AbstractText>Porcine respiratory disease complex (PRDC) is the name used to describe a clinical presentation characterized by respiratory signs and poor growth in growing-finishing pigs. Porcine circovirus type 2 (PCV2) is one of the pathogens potentially involved in the presentation of this complex, although, it has been mainly linked to PCV2-systemic disease (PCV2-SD). However, some reports have suggested that PCV2 can cause respiratory lesions in the absence of systemic lymphoid damage; this apparently different condition has been referred as PCV2-lung disease (PCV2-LD). The present study analysed retrospectively the relation between PRDC and PCV2 infection from a pathological point of view. Of the 317 selected pigs suffering from PRDC and submitted for necropsy between 1998 and 2011, the most prevalent lesions were subacute interstitial pneumonia (27.7%) and the combination of subacute interstitial pneumonia plus catarrhal-purulent bronchopneumonia (28.4%). Two hundred and twenty-six pigs were positive for PCV2 by in situ hybridization (ISH); using immunohistochemical techniques, 77 were positive for porcine reproductive and respiratory syndrome virus and 3 for swine influenza virus. Among positive pigs for PCV2 ISH, 184 animals suffered from PCV2-SD. The rest of 42 PCV2 ISH positive pigs had no lymphoid lesions and low amount of viral nucleic acid in these tissues and, therefore, did not qualify for PCVD-SD; only 9 had concomitant PCV2 ISH positivity in the lung, also to a low amount. In conclusion, all PRDC-PCV2 ISH positive cases had evidence of viral systemic infection. These results suggest that PCV2-LD is probably a negligible condition and PCV2 mainly contributes to PRDC in relation to PCV2-SD occurrence.</AbstractText><CopyrightInformation>Copyright © 2013 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ticó</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Segalés</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Martínez</LastName><ForeName>J</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>01</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Vet Microbiol</MedlineTA><NlmUniqueID>7705469</NlmUniqueID><ISSNLinking>0378-1135</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004279">DNA, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018173" MajorTopicYN="N">Circoviridae Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017925" MajorTopicYN="N">Circovirus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004279" MajorTopicYN="N">DNA, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017403" MajorTopicYN="N">In Situ Hybridization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008221" MajorTopicYN="N">Lymphoid Tissue</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012140" MajorTopicYN="N">Respiratory Tract Diseases</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013552" MajorTopicYN="N">Swine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013553" MajorTopicYN="N">Swine Diseases</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>08</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>12</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>01</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>2</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>2</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>11</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23398668</ArticleId><ArticleId IdType="pii">S0378-1135(13)00047-3</ArticleId><ArticleId IdType="doi">10.1016/j.vetmic.2013.01.001</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country><region><li>Catalogne</li></region><settlement><li>Barcelone</li></settlement><orgName><li>Université autonome de Barcelone</li></orgName></list><tree><noCountry><name sortKey="Martinez, J" sort="Martinez, J" uniqKey="Martinez J" first="J" last="Martínez">J. Martínez</name><name sortKey="Segales, J" sort="Segales, J" uniqKey="Segales J" first="J" last="Segalés">J. Segalés</name></noCountry><country name="Espagne"><region name="Catalogne"><name sortKey="Tic, G" sort="Tic, G" uniqKey="Tic G" first="G" last="Tic">G. Tic</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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